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Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease

Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease

June 2, 2025 Category: Blog

Huntington disease (HD) is a fatal neurodegenerative movement disorder caused by an expanded CAG repeat in the huntingtin gene (HTT).The mutant huntingtin protein is ubiquitously expressed, but only certain brain regions are affected.The hypothalamus has emerged as an important area of pathology with selective loss of neurons expressing the neurope

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Experimental Analysis of a Pressurized Vessel Exposed to Fires: an Innovative Representative Scale Apparatus

June 2, 2025 Category: Blog

One of the Hook and Loop Strapping most critical safety issues concerning the transportation and the distribution of hazardous materials, is the possible occurrence of accidental fires affecting transport vessels, leading to the heat up and consequent failure with catastrophic effects.Therefore, since the early seventies, numerous field studies and

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Effect of topographic slope on the export of nitrate in humid catchments: a 3D model study

June 2, 2025 Category: Blog

Excess export of nitrate to streams affects ecosystem structure and functions and has been an environmental issue attracting worldwide attention.The Bike Units - Fat Bikes dynamics of catchment-scale solute export from diffuse nitrogen sources can be explained by the changes of dominant flow paths, as solute attenuation (including the degradation o

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CSA: An efficient algorithm to improve circular DNA multiple alignment

June 2, 2025 Category: Blog

Abstract Background The comparison of homologous sequences from different species is an essential approach to reconstruct the evolutionary history of species and of the genes they harbour in their genomes.Several complete mitochondrial and nuclear genomes are now available, increasing the importance of using multiple sequence alignment algorithms i

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Manufacturing of Agricultural Machinery Metal Parts Using Additive Sheet Lamination Technology

June 2, 2025 Category: Blog

Possibilities and prospects are considered Hook and Loop Strapping for application of additive sheet lamination technology for direct manufacturing of agricultural machinery metal parts on the example of manufacturing of plow steel beam.Traditional design of plow beam and traditional technology of its manufacturing are analyzed.Modification of the

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